Reliable Detection of HDV RNA Independent of the Genotype

Introduction Hepatitis Delta Virus (HDV) infection is considered to be the most severe hepatic disease; worldwide more than 15 million people are co-infected. Determining HDV RNA is important to distinguish an active from a non-active infection. HDV RNA is the marker of active HDV infection and can guide the clinician on his recommendation of therapy. Interferon-alpha is currently the only available treatment option leading to suppression of HDV RNA in 25 % 30 % of patients [1]. However, pegylated interferon therapy is sometimes associated with severe side effects and only a minority of patients are eligible for treatment. Novel alternative treatment options are currently in early clinical trials.